https://medixway.com/amitriptyline-vs-lexapro/ 

Amitriptyline and Lexapro are both effective prescription medications used to treat depression, but they belong to different drug classes and work in distinct ways. Amitriptyline is a tricyclic antidepressant (TCA) that increases levels of serotonin and norepinephrine in the brain to improve mood and relieve anxiety. Lexapro (escitalopram), on the other hand, is a selective serotonin reuptake inhibitor (SSRI) that primarily boosts serotonin levels, often causing fewer side effects than older antidepressants. While Amitriptyline can be effective for patients with depression and chronic pain, Lexapro is generally preferred for its better tolerability and lower risk of sedation. Both should be taken under close medical supervision to ensure safe, effective treatment and gradual improvement in mood and emotional well-being.