https://medixway.com/oxycodone-and-ibuprofen/ 

Combining Oxycodone and Ibuprofen can be an effective strategy for managing moderate to severe pain. Oxycodone is an opioid that works by altering the way the brain and nervous system perceive pain, while Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation and swelling. When used together under medical supervision, this combination can provide more comprehensive pain relief than either medication alone, potentially allowing lower doses of Oxycodone. However, patients must follow dosing instructions carefully to avoid side effects such as gastrointestinal irritation from Ibuprofen or drowsiness and dependence risks from Oxycodone. Always consult a healthcare provider before combining these medications to ensure safe and effective pain management.