Yes, Can Metoprolol Cause ED, which is a beta-blocker commonly prescribed for high blood pressure and heart-related conditions, can potentially cause erectile dysfunction (ED) as a side effect. Beta-blockers can affect blood flow and circulation, which may impact the ability to achieve or maintain an erection. Some beta-blockers can influence hormone levels, including testosterone, which plays a key role in sexual function. If you experience ED while taking metoprolol, consult your healthcare provider. The stress of managing a chronic condition or side effects of medication can also contribute to psychological factors that lead to ED.